The regulation of gene expression of hemolysins ( such as streptolysin S ) is a system repressed in the presence of iron.
2.
Streptolysin O is hemolytically active only in a reversibly reduced state, unlike streptolysin S, which is stable in the presence of oxygen.
3.
Types include streptolysin O ( SLO ), which is oxygen-labile, and streptolysin S ( SLS ), which is oxygen-stable.
4.
Significantly, there is an immunologic reaction to Streptolysin S, a toxin released by certain killed bacteria and associated with Penicillin injection, that can cause fatal cardiac syncope.
5.
Nelfinavir and simple derivatives have been found to inhibit the production of the virulence factor streptolysin S, a cytolysin produced by the human pathogen " Streptococcus pyogenes ".
6.
Streptolysin S ( SLS ) is perhaps the most well-studied and most famous LAP, in part because the structure is still unknown since the discovery of SLS in 1901.
7.
The clinical presentation is dominated by severe sepsis and the formation of microabscesses, and a relationship between disease severity and the expression of the virulence factors Streptolysin S and SPEGdys has been inferred.
8.
Other bioactive RiPPs include the antibiotics cyclothiazomycin and bottromycin, the ultra-narrow spectrum antibiotic plantazolicin, and the cytotoxin patellamide A . Streptolysin S, the toxic virulence factor of " Streptococcus pyogenes ", is also a RiPP . Additionally, human thyroid hormone itself is a RiPP due to its biosynthetic origin as thyroglobulin.
9.
Several toxins and secreted enzymes have been identified in " Streptococcus dysgalactiae ", including the haemolysins Streptolysin O ( SLO ) and Streptolysin S ( SLS ), and a correlation between the expression of SLO and SLS and disease severity has been inferred . " speGdys ", a homolog of the " S . pyogenes " superantigen " speG ", has been documented in some " S . dysgalactiae " strains.
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